The Coptic Orthodox Church, also known as the Coptic Orthodox Patriarchate of Alexandria, is an Oriental Orthodox Christian church based in Egypt. The head of the church and the See of Alexandria is the pope of Alexandria on the Holy Apostolic See of Saint Mark, who also carries the title of Father of fathers, Shepherd of shepherds, Ecumenical Judge and the 13th among the Apostles. The See of Alexandria is titular. The Coptic pope presides from Saint Mark's Coptic Orthodox Cathedral in the Abbassia District in Cairo. The church follows the Coptic Rite for its liturgy, prayer and devotional patrimony. Adherents of the Coptic Orthodox Church make up Egypt's largest and most significant minority population, and the largest population of Christians in the Middle East and North Africa (MENA). They make up the largest percentage of approximately 20 million Christians in Egypt.

The Council of Chalcedon was the fourth ecumenical council of the Christian Church. It was convoked by the Roman emperor Marcian. The council convened in the city of Chalcedon, Bithynia from 8 October to 1 November 451. The council was attended by over 520 bishops or their representatives, making it the largest and best-documented of the first seven ecumenical councils. The principal purpose of the council was to re-assert the teachings of the ecumenical Council of Ephesus against the teachings of Eutyches and Nestorius. Such doctrines viewed Christ's divine and human natures as separate (Nestorianism) or viewed Christ as solely divine (monophysitism).