Craignethan Castle is a ruined castle in South Lanarkshire, Scotland. It is located above the River Nethan, a tributary of the River Clyde, at NS816464. The castle is two miles west of the village of Crossford, and 4.5 miles north-west of Lanark. Built in the first half of the 16th century, Craignethan is recognised as an excellent early example of a sophisticated artillery fortification, although its defences were never fully tested.

Archibald Wauchope of Niddrie Scottish landowner and rebel.