Creighton Preparatory School is a private, Jesuit high school for boys in Omaha, Nebraska, United States. It was established in 1878 under the name Creighton College and is located in the Roman Catholic Archdiocese of Omaha. Creighton College was founded by John A. Creighton and named after Edward Creighton, developer of the transcontinental telegraph line. It was founded from a $100,000 grant and donated to the Catholic Church, leading to its inception as a Jesuit institution. Creighton College separated into Creighton University and Creighton Preparatory School in 1958. Over the 142 years since its founding, Creighton Prep has grown from an initial class of 120 students to a student body of 1021 individuals (2016).

The Archdiocese of Omaha is a Latin Church ecclesiastical territory or diocese of the Catholic Church in northeastern Nebraska in the United States. Its current archbishop, George Joseph Lucas, was installed in Omaha on July 22, 2009.