Cuautitlán Izcalli is a city and one of the 125 municipalities that make up the State of Mexico. Its municipal seat is Cuautitlán Izcalli. It is located in the Valley of Mexico area, and is part of the Metropolitan area of Mexico City. It borders to the north and northwest with Tepotzotlán, to the northeast and to the east with Cuautitlán, to the south with Tlalnepantla de Baz, to the southeast with Tultitlán, to the southwest with Atizapán de Zaragoza and to the west with the municipality of Nicolás Romero.

Mexico is a state in central Mexico that is divided into 125 municipalities. According to the 2020 Mexican census, it is the most populated state with 16,992,418 inhabitants and the 8th smallest by land area spanning 22,351.8 square kilometres (8,630.1 sq mi).