Cumberland County is a county located in the U.S. state of Illinois. As of the 2020 census, the population was 10,450. Its county seat is Toledo.

U.S. Route 45 in the state of Illinois is a major north–south U.S. Highway that runs from the Brookport Bridge over the Ohio River at Brookport north through rural sections of eastern Illinois and then through the suburbs of Chicago to the Wisconsin state line east of Antioch. This is a distance of 428.99 miles (690.39 km). US 45 is the longest numbered route in Illinois.