Cuyahoga Valley is a neighborhood on the Central and South Side of Cleveland, Ohio, located along the Cuyahoga River. Formerly known as Industrial Valley, the neighborhood was originally limited to only one section of the geographic Cuyahoga River Valley, but the city expanded it in 2012 to include the entire valley area. The present neighborhood includes the Flats and extends from the peninsula of Whiskey Island on Lake Erie in the north to the borders of the suburbs of Newburgh Heights and Cuyahoga Heights in the south. To the east, it borders Downtown Cleveland and the neighborhoods of Broadway–Slavic Village and Central. To the west, it borders the neighborhoods of Detroit–Shoreway, Ohio City, Tremont, and Brooklyn Centre.

The Flats is a mixed-use industrial, recreational, entertainment, and residential area of the Cuyahoga Valley neighborhood of Cleveland, Ohio, U.S. The name reflects its low-lying topography on the banks of the Cuyahoga River.