The Cuyama Valley is a valley along the Cuyama River in Central California, in northern Santa Barbara, southern San Luis Obispo, southwestern Kern, and northwestern Ventura counties. It is about two hours driving time from both Los Angeles and the Santa Barbara area.

The Cuyama River is a 118-mile-long (190 km) river in southern San Luis Obispo County, northern Santa Barbara County, and northern Ventura County, in the U.S. state of California. It joins the Sisquoc River forming the Santa Maria River. The river's name comes from an Indian village named for the Chumash word kuyam, meaning "clam" or "freshwater mollusk".