The Cybo or Saint Lawrence Chapel is the second side chapel in the right-hand aisle of the Basilica of Santa Maria del Popolo in Rome. For the beauty of its paintings, the preciousness of marble revetments covering its walls and the importance of the artists involved in its construction the chapel is regarded one of the most significant sacral monuments erected in Rome in the last quarter of the 17th century.

The Parish Basilica of Santa Maria del Popolo is a titular church and a minor basilica in Rome run by the Augustinian order. It stands on the north side of Piazza del Popolo, one of the most famous squares in the city. The church is hemmed in between the Pincian Hill and Porta del Popolo, one of the gates in the Aurelian Wall as well as the starting point of Via Flaminia, the most important route from the north. Its location made the basilica the first church for the majority of travellers entering the city. The church contains works by several famous artists, such as Raphael, Gian Lorenzo Bernini, Caravaggio, Alessandro Algardi, Pinturicchio, Andrea Bregno, Guillaume de Marcillat and Donato Bramante.