OA-8E was the ninth flight of the Orbital ATK uncrewed resupply spacecraft Cygnus and its eighth flight to the International Space Station (ISS) under the Commercial Resupply Services (CRS-1) contract with NASA. The mission launched on 12 November 2017 at 12:19:51 UTC. Orbital and NASA jointly developed a new space transportation system to provide commercial cargo resupply services to the International Space Station (ISS). Under the Commercial Orbital Transportation System (COTS) program, then Orbital Sciences designed and built Antares, a medium-class launch vehicle; Cygnus, an advanced maneuvering spacecraft, and a Pressurized Cargo Module which is provided by Orbital's industrial partner Thales Alenia Space.

Cygnus is an expendable American cargo spacecraft developed by Orbital Sciences Corporation but manufactured and launched by Northrop Grumman Space Systems as part of NASA's Commercial Resupply Services (CRS) program. It is usually launched by Northrop Grumman's Antares rocket from the Wallops Flight Facility, although three flights were on ULA's Atlas V and three are planned for SpaceX's Falcon 9, in both cases launching from Cape Canaveral Space Force Station. It transports supplies to the International Space Station (ISS) following the retirement of the American Space Shuttle. Since August 2000, ISS resupply missions have been regularly flown by the Russian Progress spacecraft, as well as by the European Automated Transfer Vehicle, and the Japanese H-II Transfer Vehicle. With the Cygnus spacecraft and the SpaceX Dragon, NASA seeks to increase its partnerships with domestic commercial aviation and aeronautics industry.