Cyprus participated in the Eurovision Song Contest 2021 in Rotterdam, the Netherlands. The Cypriot broadcaster Cyprus Broadcasting Corporation (CyBC) internally selected Elena Tsagrinou as its representative with the song "El Diablo". "El Diablo" was written and composed by Thomas Stengaard, Laurell Barker, Oxa, and Jimmy Thörnfeldt. Cyprus performed 8th in the first semi-final of the Eurovision Song Contest 2021, held on 18 May 2021, and placed 6th, receiving 170 points. The entry qualified for the final held four days later, where the nation placed 16th with 94 points.

Greece participated in the Eurovision Song Contest 2021 in Rotterdam, Netherlands. Greek-Dutch singer Stefania was internally selected by the Hellenic Broadcasting Corporation (ERT) to represent the nation with the song "Last Dance", written by Dimitris Kontopoulos, Arcade, and Sharon Vaughn. Stefania was due to compete in the 2020 contest with "Supergirl" before that event's eventual cancellation.