Cyrildene is a suburb of Johannesburg, South Africa, predominantly home to Chinese people. The area is found east of the Johannesburg CBD and is surrounded by the suburbs of Linksfield, Observatory and Bruma. It is noted for a new Chinatown that exists on Derrick Avenue. This new Chinatown is now considered as the main Chinatown in Johannesburg, replacing the declining Chinatown on Commissioner Street in the inner-city of Johannesburg. It is located in Region F of the City of Johannesburg Metropolitan Municipality.

Commissioner Street is a major one-way street (westwards) in the Central Business District of Johannesburg, South Africa. It runs from the M31 to the R41, and is indicated as the R24. The Carlton Centre, the 2nd-tallest building in Africa, is located on the street, as is the southern end of Newtown. There is little evidence of Commissioner Street's exact origin, although it is known that this street played a role in the development of Johannesburg.