Cytopathology is a branch of pathology that studies and diagnoses diseases on the cellular level. The discipline was founded by George Nicolas Papanicolaou in 1928. Cytopathology is generally used on
Micrograph of a pilocytic astrocytoma, showing characteristic bipolar cells with long pilocytic (hair-like) processes. Smear preparation. H&E stain
A micrograph of an exfoliative cytopathology specimen (Pap test, Pap stain)
Cervical squamous cells with cornflake artifact, when some mounting medium evaporates before coverslipping.
Histopathology is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or sur
Cytopathology
…was founded by George Nicolas Papanicolaou in 1928. Cytopathology is generally used on samples of free cells or tissue fragments, in contrast to histopathology, which studies whole tissues. Cytopathology is frequently, less precisely, called "cytology", which means "the study of cells". Cytopathology is commonly…
Microscope image showing contraction band necrosis, a histopathologic finding of myocardial infarction (heart attack).
Items used for submitting specimens: (Biopsy) wrap, (biopsy) sponge, (tissue processing) cassette and (biopsy) bag.
There is also the option to make a "touch prep", wherein a glass slide is simply pressed against the tissue and then exposed to a fixative solution. The glass slide can then be stained and examined. This is feasible for an initial evaluation of suspected lymphomas.
Orientation (lowest magnification): In this case oriented by the skin surface (green). A lesion is seen (red) and its demarcation can be discerned (diffuse in this case)