Wine in the Czech Republic is produced mainly in southern Moravia, although a few vineyards are located in Bohemia. However, Moravia accounts for around 96% of the country's vineyards, which is why Czech wine is more often referred to as Moravian wine. Production centers on local grape varieties, but there has been an increase in the production of established international strains such as Cabernet Sauvignon.

The South Moravian Region, or just South Moravia, is an administrative unit of the Czech Republic, located in the south-western part of its historical region of Moravia. The region's capital is Brno, the nation's 2nd largest city. South Moravia is bordered by the South Bohemian Region to the west, Vysočina Region to the north-west, Pardubice Region to the north, Olomouc Region to the north-east, Zlín Region to the east, Trenčín and Trnava Regions, Slovakia to the south-east and Lower Austria, Austria to the south.