The Děčín–Dresden railway, also called the Elbe Valley Railway is an electrified main line in Saxony and the Czech Republic. Formerly called the Saxon-Bohemian State Railway, the line is part of the Dresden to Prague route and is one of Europe's most important trunk routes (Magistralen). It runs along the Elbe Valley from Děčín via Bad Schandau and Pirna to Dresden. The first section of the line was opened in 1848 and is one of the oldest lines in Germany.

Děčín is a city in the Ústí nad Labem Region of the Czech Republic. It has about 47,000 inhabitants. It is the 7th largest municipality in the country by area. Děčín is an important traffic junction.