DNA repair
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In molecular biology, DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk f
DNA damage resulting in multiple broken chromosomes
Diagram of DNA repair.
Structure of the base-excision repair enzyme uracil-DNA glycosylase excising a hydrolytically-produced uracil residue from DNA. The uracil residue is shown in yellow.
DNA ligase, shown above repairing chromosomal damage, is an enzyme that joins broken nucleotides together by catalyzing the formation of an internucleotide ester bond between the phosphate backbone and the deoxyribose nucleotides.
Cellular senescence
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Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibro
DNA repair
…amount of DNA damage or can no longer effectively repair its DNA may enter one of three possible states: an irreversible state of dormancy, known as senescence apoptosis, a form of programmed cell death…
Top: Primary mouse embryonic fibroblast cells (MEFs) before senescence. Spindle-shaped. Bottom: MEFs became senescent after passages. Cells grow larger, flatten in shape, and express senescence-associated β-galactosidase (SABG, blue areas), a marker of cellular senescence.
SASPs in glial cell senescence