Dakota Wesleyan University (DWU) is a private Methodist university in Mitchell, South Dakota. It was founded in 1885 and is affiliated with the United Methodist Church. The student body averages slightly fewer than 800 students. The campus of the university is listed on the National Register of Historic Places.

Mitchell is a city in and the county seat of Davison County, South Dakota, United States. The population was 15,660 at the 2020 census making it the sixth most populous city in South Dakota.