Daniel Earle McGugin was an American football player and coach, as well as a lawyer. He served as the head football coach at Vanderbilt University in Nashville, Tennessee from 1904 to 1917 and again from 1919 to 1934, compiling a record of 197–55–19, he is the winningest head coach in the history of the university. McGugin was inducted into the College Football Hall of Fame as a coach in 1951 as part of its inaugural class, he was the brother-in-law of University of Michigan coach Fielding H. Yost. McGugin was born in July 1879 on a farm near Iowa, he was the son of Benjamin Franklin Melissa McGugin. He was of Irish descent. McGugin saw the baton twirling skills of W. W. Wharton in Tingley for a Sunday evening church service one day in 1896 and was intrigued. Wharton, Drake University's first football coach, suggested. "Come to Drake University", Wharton suggested, "and we'll make you as fine a tackle as there is." McGugin enrolled at Drake University and received a Bachelor of Arts degree in 1901.
He played football at Drake for two years at the guard and tackle positions and "was considered one of the best players that Drake had." After one victory he purchased a small brass cannon and fired it at regular fifteen-minute intervals, nodding politely to neighbors' Sabbath complaints and merrily blasting away. After graduating from Drake, McGugin enrolled in law school at the University of Michigan. While there, McGugin played college football for Fielding H. Yost, he was a player on Michigan's "Point-a-Minute" teams that outscored their opponents, 1,211 to 12 in 1901 and 1902, served as Yost's assistant coach at Michigan in 1903. A profile of McGugin in the 1903 University of Michigan yearbook noted McGugin is the lightest guard that Michigan has had in the last ten years, but he has not met his match during the past two seasons.... As a guard he is nervy, he keeps the advantage. Although a hard player he goes into each scrimmage with as much composure as if he were walking along the campus.
McGugin, although good in every department of his position, has two qualities that are pre-eminent: namely, making interference and opening holes. Heston has been fortunate this year in having a good interference, part of that interference has been McGugin. McGugin was married to Virginia Louise Fite on December 6, 1905, in Michigan, his former coach, Fielding Yost, was married to Eunice Fite, making McGugin and Yost brothers-in-law. Yost was best man at McGugin's wedding. After the last game of the 1902 season, Vanderbilt head coach Walter H. Watkins announced his resignation. Vanderbilt made an effort to secure the services of McGugin's teammate at Michigan, Neil Snow, the University of Nashville football coach. Snow resigned from Nashville never to coach again. Vanderbilt was coached by James H. Henry for one season in 1903. In 1904, McGugin wrote to Vanderbilt University asking for its head coaching position, was hired at a salary of $850 per year plus board. McGugin had written to Western Reserve, was prepared to accept the job there when he received the telegram saying he received the Vanderbilt job.
Despite Western Reserve offering $1,000, McGugin preferred the chance to see the South. McGugin remained the head football coach for the Vanderbilt Commodores from 1904 to 1917 and from 1919 to 1934. During his tenures, the Vanderbilt Commodores compiled a 197–55–19 record, had a.762 winning percentage, won 11 conference titles. He had numerous intersectional triumphs: defeating the Carlisle Indians in 1906, tying the Navy Midshipmen in 1907, the Yale Bulldogs in 1910, the Michigan Wolverines in 1922; the Vanderbilt athletics office building, the McGugin Center, bears his name. McGugin was named to the Vanderbilt Athletics Hall of Fame as part of its inaugural class. McGugin used his mentor Yost's short punt formation. In his first career game, McGugin's team defeated Mississippi A&M, 61–0, he went on to win his next two games by 60 points as well, against Georgetown 66–0 and against Mississippi 69–0. "The whole South read that 69–0 score and gasped." He remains the only coach in NCAA history to win his first three games by 60 points.
He won each of his first 11 games by more than 20 points. Vanderbilt outscored their opponents 474–4 during his first year; the 1905 team suffered its only loss to Michigan. Vanderbilt crushed a strong Sewanee squad 68–4. One publication claims "The first scouting done in the South was in 1905, when Dan McGugin and Captain Innis Brown, of Vanderbilt went to Atlanta to see Sewanee play Georgia Tech."In 1906 his team defeated Carlisle, had a third-team Walter Camp All-American in Owsley Manier, were for some writers the entire All-Southern eleven. McGugin had his team practice the pass by playing baseball with a football; the next season Vanderbilt tied Navy and met rival Sewanee, in a battle of the unbeaten for the mythical crown of the South, won using a trick double-pass play. Sewanee led 12–11 with twelve minutes to play. At McGugin's signal, the Commodores went into a freakish formation in which Stein Stone remained at center but all the other players shifted to his left. Quarterback Hugh Potts took the snap and lateraled the ball to Vaughn Blake, who lateraled it across to Bob Blake, who had lined up deep in punt formation, as Stone ran down the field.
The Socialist Workers Party of Greece is an affiliate of the International Socialist Tendency. It is the second largest organisation in IST after the British Socialist Workers Party. SEK originated among a group of exiled Greek students in London, led by Maria Styllou and Panos Garganas, a group of Greek students during the occupations of universities against the Greek dictatorship. In the beginning they organised themselves as the Socialist Revolution Organisation. While in London they developed relations with the International Socialists led by Tony Cliff and were won to the politics of the IST. In the early 1980s, the OSE developed closer links with the IST, grew rapidly and in 1997 changed their name to the Socialist Workers Party. In 2001 a minority left to form the Internationalist Workers Left organisation. SEK publishes a weekly newspaper, Workers Solidarity, a bi-monthly magazine, Socialism from Below; the SEK is active in a number organisations, including the Greek "Stop the War Coalition", "United Against Racism and the threat of Fascism".
In the 2006 Greek local elections for Athens-Piraeus Super Prefecture, the SEK supported candidates under the banner "Συμμαχία για την Υπερνομαρχία" which took 1.32%. Official SEK page in Greek ANTARSYA Greek Stop the War Coalition
Interferon gamma is a dimerized soluble cytokine, the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, by others as a product of antigen-stimulated lymphocytes, it was shown to be produced in human lymphocytes. Or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; those reports contained the basic observation underlying the now employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene. IFNγ, or type II interferon, is a cytokine, critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex molecule expression. Aberrant IFNγ expression is associated with a number of autoimmune diseases.
The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, most from its immunostimulatory and immunomodulatory effects. IFNγ is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, by CD4 Th1 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFNγ is produced by non-cytotoxic innate lymphoid cells, a family of immune cells first discovered in the early 2010s; the IFNγ monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. This is shown in the structural models below; the α-helices in the core of the structure are numbered 1 to 6. The biologically active dimer is formed by anti-parallel inter-locking of the two monomers as shown below. In the cartoon model, one monomer is shown in the other in blue. Cellular responses to IFNγ are activated through its interaction with a heterodimeric receptor consisting of Interferon gamma receptor 1 and Interferon gamma receptor 2.
IFNγ binding to the receptor activates the JAK-STAT pathway. IFNγ binds to the glycosaminoglycan heparan sulfate at the cell surface. However, in contrast to many other heparan sulfate binding proteins, where binding promotes biological activity, the binding of IFNγ to HS inhibits its biological activity; the structural models shown in figures 1-3 for IFNγ are all shortened at their C-termini by 17 amino acids. Full length IFNγ is 143 amino acids long, the models are 126 amino acids long. Affinity for heparan sulfate resides within the deleted sequence of 17 amino acids. Within this sequence of 17 amino acids lie two clusters of basic amino acids termed D1 and D2, respectively. Heparan sulfate interacts with both of these clusters. In the absence of heparan sulfate the presence of the D1 sequence increases the rate at which IFNγ-receptor complexes form. Interactions between the D1 cluster of amino acids and the receptor may be the first step in complex formation. By binding to D1 HS may compete with the receptor and prevent active receptor complexes from forming.
The biological significance of heparan sulfates interaction with IFNγ is unclear. IFNγ is secreted by T helper cells, cytotoxic T cells, mucosal epithelial cells and NK cells. IFNγ is the only Type II interferon and it is serologically distinct from Type I interferons. IFNγ has antiviral and anti-tumor properties, it alters transcription in up to 30 genes producing a variety of physiological and cellular responses. Among the effects are: Promotes NK cell activity Increases antigen presentation and lysosome activity of macrophages. Activates inducible nitric oxide synthase Induces the production of IgG2a and IgG3 from activated plasma B cells Causes normal cells to increase expression of class I MHC molecules as well as class II MHC on antigen-presenting cells—to be specific, through induction of antigen processing genes, including subunits of the immunoproteasome, as well as TAP and ERAAP in addition to the direct upregulation of MHC heavy chains and B2-microglobulin itself Promotes adhesion and binding required for leukocyte migration Induces the expression of intrinsic defense factors—for example, with respect to retroviruses, relevant genes include TRIM5alpha, APOBEC, Tetherin, representing directly antiviral effects Primes alveolar macrophages against secondary bacterial infections.
IFNγ is the primary cytokine that defines Th1 cells: Th1 cells secrete IFNγ, which in turn causes more undifferentiated CD4+ cells to differentiate into Th1 cells, representing a positive feedback loop—while suppressing Th2 cell differentiation. NK cells and CD8+ cytotoxic T cells produce IFNγ. IFNγ suppresses osteoclast formation by degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production of NF-κB. A granuloma is the body's way of dealing with a substance it can not sterilize. Infectious causes of granulomas include tuberculosis, histoplasmosis, coccidioidomycosis and toxoplasmosis. Examples of non-infectious granulomatous diseases are sarcoidosis, Crohn's disease, giant-cell arteritis, granulom
Yoko Karin Zetterlund is a former USA national volleyball player. Zetterlund graduated from Waseda University in Tokyo and went on to play for the U. S. National team. In 1992, she won a bronze medal at the Barcelona Summer Olympics. After several years of professional volleyball in Japan's V. League, she retired from the sport in 1999, she has since appeared as a color commentator and "guest expert" on sports and variety shows in Japan. She played as a setter and has a spike height of 301 cm and block of 289 cm. 1992 – Summer Olympics 1992 – FIVB Super Four 1993 – NORCECA Championships 1993 – FIVB Grand Champions Cup 1994 – Goodwill Games 1994 – World Grand Prix 1994 – World Championship 1995 – Pan American Games 1995 – Canada Cup 1995 – World Grand Prix 1995 – World Cup Official website of Yoko Zetterlund Profile at The Washington Post
Greg Jarvis is a Toronto born musician and composer best known for his work leading the orchestral rock group the Flowers Of Hell. Jarvis’s compositions are informed by timbre-to-shape synesthesia, a neurological condition which causes him to see all sounds as layers of three dimensional shapes. Jarvis was born in Toronto, Ontario where he was a Royal Canadian Air Cadet band leader and served in the Canadian Army reserve forces. Jarvis worked in marketing in the 1990s at the major label BMG in Toronto, Prague and Warsaw, for Universal International in London, handling acts including Nirvana, David Bowie, Patti Smith, Dolly Parton, Sonic Youth, Malcolm McLaren, KISS, Deep Purple, The Moody Blues, along with Death In Vegas and Spiritualized with whose members he would collaborate as an artist. Jarvis worked as an executive at the BBC’s Top Of The Pops where he conducted interviews with such acts as the Spice Girls, Alice Cooper, Depeche Mode, Oasis, he is a professor at Durham College’s Media, Art, & Design School where he teaches about music history and the music industry.
He worked as a lecturer in the United Kingdom at London Metropolitan University, Buckinghamshire New University. Jarvis has given talks at Harvard University, The Juilliard School, The Kerouac School, the Art Gallery of Ontario, he wrote music related articles for the Huffington Post from 2013-2018. Prior to the Flowers of Hell, Jarvis played on Prague’s underground music scene in the 90s, in Moscow rockabilly group Merzky Beat, in The Red Stripes in the early 2000s, a London based comedy-reggae White Stripes tribute act he formed with drummer Guri Hummelsund. "We stopped when it started getting crazy big with Peel, the NME, BBC6, The Face, Duran Duran and some peripheral members of The Clash and The Sex Pistols getting into it. We signed to a Universal imprint, met The Wailers in a medieval fortress in Serbia, shot a video in Africa and felt we had to kill it before we became too known for it," Jarvis said looking back in a 2015 Irish interview. Jarvis produced and performed on an album of Northern Soul covers and originals by Emma Wilkinson, whom he managed after she won the 2001 Stars In Their Eyes TV talent series performing Dusty Springfield’s ‘Son Of A Preacher Man’.
He founded the Flowers of Hell in London, England in 2002 as a studio project, growing it into a live group in 2005 recruiting bandmates Abi Fry, Guri Hummelsund, Ruth Barlow, Steve Head, Owen James. He returned to Canada in 2007 and formed another branch of the group, expanding its line up to encompass musicians living in both Toronto and London, he composes many of the pieces performed by the band, is its main guitarist. Highlights of the group’s career include collaborating with members of their major influence Spacemen 3, Lou Reed of the Velvet Underground praising their artistry and commencing his final radio show by playing three of the groups recordings in a row, being asked by Kevin Shields to open for My Bloody Valentine during the band’s 2008 reunion, NASA’s mission control staff declaring their enjoyment of the group’s ‘space rock’ with the shuttle launch team syncing footage of a Discovery mission to the Flowers Of Hell’s ‘Sympathy For Vengeance’. Jarvis has auditory-visual synesthesia which causes him to see all sounds as abstract shapes surrounding him.
In 2013 he founded the Canadian Synesthesia Association as a way of meeting other synethetes and raising awareness of synesthesia. Jarvis did summer studies under the octogenarian beat writer Bobbie Louise Hawkins at The Jack Kerouac School of Disembodied Poetics in Boulder, Colorado, he completed a master of arts in higher education teaching for which his thesis focused on how the mind processes music and holds an Arts & Media MBA. After summiting Kilimanjaro at the age of 23, Jarvis backpacked through rural Malawi where he was requested to name a newborn baby in a mudhut village a local brought him to. Having been asked to use names from his land that had meanings, he chose Kermit. In 2015 Fonzy Kermit Mwangomba named his first born son Greg after his'white father' who had provided financial support to him throughout his life. Following a return visit to Masoko village in 2017, Jarvis raised funds for Fonzy to study to become a mechanic, as per his wish and his TV namesake. In 2010, Jarvis was chased by a group of protesters in West Papua New Guinea after photographing their activities.
He played a ukulele to convince rebel soldiers from the Organisasi Papua Merdeka that he was a musician, not a government spy. He crossed the Atlantic Ocean as a lone passenger on a working cargo freighter in 2013, intending to complete the mixing of the Flowers Of Hell’s ‘Symphony No.1’ at sea. Official website Greg Jarvis at HuffPost
Samica is a multilingual interdisciplinary scholarly book series focused on the languages and cultures of Sápmi and published by the University of Freiburg. The first volume was published in 2014; the series editors are the literary scholar Thomas Mohnike and the linguists Michael Rießler and Joshua Wilbur. The series was founded in 2014 as the follow-up to the series Kleine saamische Schriften. Just as its predecessor, Samica is intended to reach a readership interested in a wide range of topics concerning Sámi studies. Volumes include contributions to the Sámi languages and cultures as well as teaching materials and literary texts both in the original languages and in translation; as of October 2018, four volumes have been published, a fifth is scheduled to appear in the near future. Samica is non-profit in the sense that any revenue accrued from the sale of books is used only in the production/publication of new books. In addition to having institutional assist by the University of Freiburg, various organizations in the Nordic countries have provided financial support for individual volumes in the series.
The various volumes have been edited both by the series editors in Freiburg and Strasbourg and by the respective authors and translators. Volume 1, the German translation of a text by Nils-Aslak Valkeapää, premiered on the main stage for the guest of honor pavilion Finland at the Frankfurt Book Fair in 2014. Volume 4 is an anthology representing Sámi poetry between tradition and modernity in German translation and the parallel original versions. Volume 5 is the German translation of a scene play about the live of Johan Turi by Harald Gaski and Gunnar H. Gjengset, performed as part of the art exhibition HOUSE OF NORWAY in Frankfurt by Beaivváš Sámi Našunálateáhter. Both books premiered on the main stage for the guest of honor pavilion Norway at the Frankfurt Book Fair in 2019. Whereas the books mentioned above represent various genres of fictional literature, volume 2 is a contribution to language planning for the endangered Pite Sámi language and has contributed to gain official recognition of this written language.
1 Grüße aus Lappland / Nils-Aslak Valkeapää, translated by Johanna Domokos & Gruppe Bⁱ. - Freiburg: Skandinavisches Seminar der Albert-Ludwigs-Universität Freiburg. 2014. ISBN 978-3-9816835-0-9 2 Pitesamisk ordbok: Samt stavningsregler / Joshua Wilbur - Freiburg: Skandinavisches Seminar der Albert-Ludwigs-Universität Freiburg. 2014. ISBN 978-3-9816835-1-6 3 Skoltesamiske tekster fra Neiden 4 Worte verschwinden / fliegen / zum blauen Licht: Samische Lyrik von Joik bis Rap / Johanna Domokos, Michael Rießler & Christine Schlosser, translated by Christine Schlosser - Freiburg: Skandinavisches Seminar der Albert-Ludwigs-Universität Freiburg. 2019. ISBN 978-3-9816835-3-0 5 Johan Turi: Ein Bühnenstück mit einem Joik von Áilloš / Harald Gaski & Gunnar H. Gjengset, translated by Tatjana Krzemien, Anna-Sophia Mäder & Michael Rießler - Freiburg: Skandinavisches Seminar der Albert-Ludwigs-Universität Freiburg. 2019. ISBN 978-3-9816835-4-7 Samica homepage