The Dandenong Creek is an urban creek of the Port Phillip catchment, located in the eastern and south-eastern Greater Melbourne region of the Australian east coast state of Victoria. The creek descends approximately 550 metres (1,800 ft) over its course of 53 kilometres (33 mi) before joining the Eumemmerring Creek to form the Patterson River and eventually draining into the Beaumaris Bay.

The Dandenong Creek Trail is a shared use path for cyclists and pedestrians, which follows Dandenong Creek through the outer eastern and south-eastern suburbs of Melbourne, Victoria, Australia.