Danesfield House in Medmenham, near Marlow, Buckinghamshire, England, in the Chiltern Hills is a former country house now used as a hotel and spa. The house stands on a plateau which shelves steeply down to the River Thames to the south.

Medmenham is a village and civil parish in south-west Buckinghamshire, England. It is on the River Thames, about 3+1⁄2 miles (5.6 km) southwest of Marlow and 3 miles (4.8 km) east of Henley-on-Thames. The parish also includes Danesfield, a housing estate predominantly for RAF officers, although families of other ranks from the RAF, Royal Navy and British Army also live there.