The House of Danneskiold-Samsøe is a Danish family of high nobility associated with the Danish Royal Family, and who formerly held the island of Samsø as a fief.

Danish nobility is a social class and a former estate in the Kingdom of Denmark. The nobility has official recognition in Denmark, a monarchy. Its legal privileges were abolished with the constitution of 1849. Some of the families still own and reside in castles or country houses. A minority of nobles still belong to the elite, and they are as such present at royal events where they hold court posts, are guests, or are objects of media coverage, for example Kanal 4's TV-hostess Caroline Fleming née Baroness Iuel-Brockdorff. Some of them own and manage companies or have leading positions within business, banking, diplomacy and NGOs.