The Danube Commission is concerned with the maintenance and improvement of navigation conditions of the Danube River, from its source in Germany to its outlets in Romania and Ukraine, leading to the Black Sea. It was established in 1948 by seven countries bordering the river, replacing previous commissions that had also included representatives of non-riparian powers. Its predecessor commissions were among the first attempts at internationalizing the police powers of sovereign states for a common cause.

The Danube River has been a trade waterway for centuries, but with the rise of international borders and the jealousies of national states, commerce and shipping has often been hampered for reasons of conflict and parochialism rather than cooperation between various powers in control of parts of the river. In addition, natural features of the river, most notably the sanding of the delta, has often hampered international trade. For these reasons, diplomats over the decades have worked to internationalize the Danube River in an attempt to allow commerce to flow as smoothly as possible.