Daphne is a city in Baldwin County, Alabama, United States, on the eastern shoreline of Mobile Bay. The city is located along I-10, 11 miles east of Mobile and 170 miles southwest of the state capital of Montgomery. The 2010 United States Census lists the population of the city as 21,570, making Daphne the most populous city in Baldwin County. It is a principal city of the Daphne-Fairhope-Foley metropolitan area, which includes all of Baldwin County.

Baldwin County is a county located in the southwestern part of the U.S. state of Alabama, on the Gulf coast. It is one of only two counties in Alabama that border the Gulf of Mexico, along with Mobile County. As of the 2020 census, the population was 231,767, making it the fourth-most populous county in Alabama. The county seat is Bay Minette. The county is named after the founder of the University of Georgia, Senator Abraham Baldwin.