Darb El Arba'īn is the easternmost of the great north–south Trans-Saharan trade routes. The Darb El Arba'īn route was used to move trade goods, livestock and slaves via a chain of oases from the interior of Africa to portage on the Nile River and thence to the rest of the world.

Trans-Saharan trade is trade between sub-Saharan Africa and North Africa that requires travel across the Sahara. Though this trade began in prehistoric times, the peak of trade extended from the 8th century until the early 17th century CE. The Sahara once had a different climate and environment. In Libya and Algeria, from at least 7000 BCE, pastoralism, large settlements and pottery were present. Cattle were introduced to the Central Sahara (Ahaggar) between 4090 to 3500 BCE. Remarkable rock paintings in arid regions portray flora and fauna that are not present in the modern desert.