Darién is a province in Panama whose capital city is La Palma. With an area of 11,896.5 km2 (4,593.3 sq mi), it is located at the eastern end of the country and bordered to the north by the province of Panamá and the region of Kuna Yala. To the south, it is bordered by the Pacific Ocean and Colombia. To the east, it borders Colombia; to the west, it borders the Pacific Ocean and the province of Panama.

The Darién Gap is a geographic region that connects the American continents, stretching across southern Panama's Darién Province and the northern portion of Colombia's Chocó Department. Consisting of a large watershed, dense rainforest, and mountains, it is known for its remoteness, difficult terrain, and extreme environment, with a reputation as one of the most inhospitable regions in the world. Nevertheless, as the only land bridge between North and South America, the Darién Gap has historically served as a major route for both humans and wildlife.