Darién is a province in Panama whose capital city is La Palma. With an area of 11,896.5 km2 (4,593.3 sq mi), it is located at the eastern end of the country and bordered to the north by the province of Panamá and the region of Kuna Yala. To the south, it is bordered by the Pacific Ocean and Colombia. To the east, it borders Colombia; to the west, it borders the Pacific Ocean and the province of Panama.

Guna Yala, formerly known as San Blas, is a comarca indígena in northeast Panama. Guna Yala is home to the indigenous people known as the Gunas. Its capital is Gaigirgordub. It is bounded on the north by the Caribbean Sea, on the south by the Darién Province and Emberá-Wounaan, on the east by Colombia, and on the west by the province of Colón.