The Darien scheme was an unsuccessful attempt, backed largely by investors of the Kingdom of Scotland, to gain wealth and influence by establishing New Caledonia, a colony in the Darién Gap on the Isthmus of Panama, in the late 1690s. The plan was for the colony, located on the Gulf of Darién, to establish and manage an overland route to connect the Pacific and Atlantic Oceans. The backers knew that the first sighting of the Pacific Ocean by Balboa was after crossing the isthmus through Darién. The expedition also took sovereignty over 'Crab Isle' in 1698, yet sovereignty was short-lived. The attempt at settling the area did not go well; more than 80 per cent of participants died within a year, and the settlement was abandoned twice.

Darién is a province in Panama whose capital city is La Palma. With an area of 11,896.5 km2 (4,593.3 sq mi), it is located at the eastern end of the country and bordered to the north by the province of Panamá and the region of Kuna Yala. To the south, it is bordered by the Pacific Ocean and Colombia. To the east, it borders Colombia; to the west, it borders the Pacific Ocean and the province of Panama.