The Daughters of Bilitis, also called the DOB or the Daughters, was the first lesbian civil and political rights organization in the United States. The organization, formed in San Francisco in 1955, was initially conceived as a secret social club, an alternative to lesbian bars, which were subject to raids and police harassment.

The Lavender Scare was a moral panic about homosexual people in the United States government which led to their mass dismissal from government service during the mid-20th century. It contributed to and paralleled the anti-communist campaign which is known as McCarthyism and the Second Red Scare. Gay men and lesbians were said to be national security risks and communist sympathizers, which led to the call to remove them from state employment. It was thought that gay people were more susceptible to being manipulated, which could pose a threat to the country. Lesbians were at less risk of persecution than gay men, but some lesbians were interrogated or lost their jobs.