David Zeisberger was a Moravian clergyman and missionary among the Native American tribes who resided in the Thirteen Colonies. He established communities of Munsee (Lenape) converts to Christianity in the valley of the Muskingum River in Ohio; and for a time, near modern-day Amherstburg, Ontario.

The Moravian Church, or the Moravian Brethren, formally the Unitas Fratrum, is one of the oldest Protestant denominations in Christianity, dating back to the Bohemian Reformation of the 15th century and the Unity of the Brethren founded in the Kingdom of Bohemia, sixty years before Luther's Reformation.