Daytop, or Daytop Village, is a drug addiction treatment organization with facilities in New York City. It was founded in 1963 in Tottenville, Staten Island by Daniel Harold Casriel along with Monsignor William B. O'Brien, a Roman Catholic priest and founder and president of the World Federation of Therapeutic Communities. Ron Brancato from the Pelham Bay area of Bronx New York, Program Director and former resident of Synanon, California. Synanon was the only other drug rehabilitation program until Daytop Village opened.

"Just Say No" was an advertising campaign prevalent during the 1980s and early 1990s as a part of the U.S.-led war on drugs, aiming to discourage children from engaging in illegal recreational drug use by offering various ways of saying no. The slogan was created and championed by Nancy Reagan during her husband's presidency.