The DePaul Blue Demons men's basketball program is the NCAA Division I intercollegiate men's basketball program of DePaul University in Chicago, Illinois. The team competes in the Big East Conference. DePaul's last NCAA tournament victory was in 2004. DePaul's NCAA tournament record since the end of the 1991–92 season is 1–2, spanning the last 30 tournaments played.

DePaul University is a private Catholic research university in Chicago, Illinois. Founded by the Vincentians in 1898, the university takes its name from the 17th-century French priest Saint Vincent de Paul. In 1998, it became the largest Catholic university in terms of enrollment in North America. Following in the footsteps of its founders, DePaul places special emphasis on recruiting first-generation students and others from disadvantaged backgrounds.