DePauw University is a private liberal arts college in Greencastle, Indiana. It was founded in 1837 as Indiana Asbury University and changed its name to DePauw University in 1884. The college has a Methodist heritage and was founded to be an ecumenical institution of national stature, "conducted on the most liberal principles, accessible to all religious denominations and designed for the benefit of our citizens in general".

Francis Asbury was a British-American Methodist minister who became one of the first two bishops of the Methodist Episcopal Church in the United States. During his 45 years in the colonies and the newly independent United States, he devoted his life to ministry, traveling on horseback and by carriage thousands of miles to those living on the frontier.