The DeWitt Clinton of the Mohawk and Hudson Railroad (M&H) was an American steam locomotive and the first working steam locomotive built for service in New York state.

DeWitt Clinton was an American politician and naturalist. He served as a United States senator, as the mayor of New York City, and as the sixth governor of New York. In the last capacity, he was largely responsible for the construction of the Erie Canal. Clinton was a major candidate for the American presidency in the election of 1812, challenging incumbent James Madison.