De Beque is a statutory town located in Mesa County, Colorado. The population was 493 at the time of the 2020 census. De Beque is a part of the Grand Junction, CO Metropolitan Statistical Area. The town consists of a small grid, including a historic downtown featuring a town hall, a tavern, and several commercial businesses in historic structures. The surrounding streets include houses, several churches, and a school.

Mesa County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 155,703. The county seat and most populous municipality is Grand Junction. The county was named for the many large mesas in the area, including the Grand Mesa, which is the largest flat-topped mountain in the world.