De La Salle University, also referred to as DLSU, De La Salle or La Salle, is a private, Catholic coeducational research university run by the Institute of the Brothers of the Christian Schools in Taft Avenue, Malate, Manila, Philippines. It was established by the Christian Brothers in 1911 as De La Salle College (DLSC) in Nozaleda Street, Paco, Manila with Blimond Pierre Eilenbecker, FSC serving as director, and is the first De La Salle school in the Philippines. The college was granted university status on February 19, 1975, and is the oldest constituent of De La Salle Philippines (DLSP), a network of 16 educational institutions, established in 2006 replacing the De La Salle University System.

Taft Avenue is a major road in the south of Metro Manila. It passes through three cities in the metropolis: Manila, Pasay, and Parañaque. The road was named after the former Governor-General of the Philippines and U.S. President, William Howard Taft; the Philippines was a former commonwealth territory of the United States in the first half of the 20th century. The avenue is a component of National Route 170 (N170), a secondary road in the Philippine highway network and the entirety R-2 of the Manila arterial road network.