The de Saisset Museum at Santa Clara University opened in 1955, after Isabel de Saisset, the last member of a California pioneer family bequeathed her estate to the University of Santa Clara. The museum owns nearly 10,000 art pieces and historical artifacts, including the work of early Californian artist and university alumnus Ernest de Saisset and a considerable collection of California mission artifacts. The de Saisset recently completed a major renovation of its storage facilities and is open to the public free of charge.

Santa Clara University is a private Jesuit university in Santa Clara, California. Established in 1851, Santa Clara University is the oldest operating institution of higher learning in California. The university's campus surrounds the historic Mission Santa Clara de Asís which traces its founding to 1777. The campus mirrors the Mission's architectural style and is one of the finest groupings of Mission Revival architecture and other Spanish Colonial Revival styles. The university is classified as a "Doctoral/Professional" university.