In the United States, members of the Delano family include U.S. presidents Franklin Delano Roosevelt, Ulysses S. Grant and Calvin Coolidge, astronaut Alan B. Shepard, and writer Laura Ingalls Wilder. Its progenitor is Philippe de Lannoy (1602–1681), a Pilgrim of Walloon descent, who arrived at Plymouth, Massachusetts, in the early 1620s. His descendants also include Eustachius De Lannoy, Frederic Adrian Delano, Robert Redfield, and Paul Delano. Delano family forebears include the Pilgrims who chartered the Mayflower, seven of its passengers, and three signers of the Mayflower Compact.

Franklin Delano Roosevelt, commonly known by his initials FDR, was an American statesman and politician who served as the 32nd president of the United States from 1933 until his death in 1945. He was a member of the Democratic Party and is the only U.S. president to have served more than two terms. His initial two terms were centered on combating the Great Depression, while his third and fourth saw him shift his focus to America's involvement in World War II.