Delaware Route 41 (DE 41) is a highway in northwestern New Castle County, Delaware. Its southern terminus is at DE 2 and DE 62 in Prices Corner. From DE 2, the road passes through suburban areas along Newport Gap Pike, intersecting DE 48 in Hockessin and becoming Lancaster Pike. Its northern terminus is the Pennsylvania state line just north of Hockessin, and the road continues on as Pennsylvania Route 41 (PA 41) to Gap.

New Castle County is the northernmost of the three counties of the U.S. state of Delaware. As of the 2020 census, the population was 570,719, making it the most populous county in Delaware, with nearly 60% of the state's population of 989,948. The county seat is Wilmington, which is also the state's most populous city.