1.
Netherlands
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The Netherlands, also informally known as Holland is the main constituent country of the Kingdom of the Netherlands. It is a densely populated country located in Western Europe with three territories in the Caribbean. The European part of the Netherlands borders Germany to the east, Belgium to the south, and the North Sea to the northwest, sharing borders with Belgium, the United Kingdom. The three largest cities in the Netherlands are Amsterdam, Rotterdam and The Hague, Amsterdam is the countrys capital, while The Hague holds the Dutch seat of parliament and government. The port of Rotterdam is the worlds largest port outside East-Asia, the name Holland is used informally to refer to the whole of the country of the Netherlands. Netherlands literally means lower countries, influenced by its low land and flat geography, most of the areas below sea level are artificial. Since the late 16th century, large areas have been reclaimed from the sea and lakes, with a population density of 412 people per km2 –507 if water is excluded – the Netherlands is classified as a very densely populated country. Only Bangladesh, South Korea, and Taiwan have both a population and higher population density. Nevertheless, the Netherlands is the worlds second-largest exporter of food and agricultural products and this is partly due to the fertility of the soil and the mild climate. In 2001, it became the worlds first country to legalise same-sex marriage, the Netherlands is a founding member of the EU, Eurozone, G-10, NATO, OECD and WTO, as well as being a part of the Schengen Area and the trilateral Benelux Union. The first four are situated in The Hague, as is the EUs criminal intelligence agency Europol and this has led to the city being dubbed the worlds legal capital. The country also ranks second highest in the worlds 2016 Press Freedom Index, the Netherlands has a market-based mixed economy, ranking 17th of 177 countries according to the Index of Economic Freedom. It had the thirteenth-highest per capita income in the world in 2013 according to the International Monetary Fund, in 2013, the United Nations World Happiness Report ranked the Netherlands as the seventh-happiest country in the world, reflecting its high quality of life. The Netherlands also ranks joint second highest in the Inequality-adjusted Human Development Index, the region called Low Countries and the country of the Netherlands have the same toponymy. Place names with Neder, Nieder, Nether and Nedre and Bas or Inferior are in use in all over Europe. They are sometimes used in a relation to a higher ground that consecutively is indicated as Upper, Boven, Oben. In the case of the Low Countries / the Netherlands the geographical location of the region has been more or less downstream. The geographical location of the region, however, changed over time tremendously
2.
South Holland
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South Holland is a province in the midwestern Netherlands. It has a population of just over 3.6 million, situated on the North Sea in the west of the Netherlands, South Holland covers an area of 3,403 km2, of which 585 km2 is water. It borders North Holland to the north, Utrecht and Gelderland to the east, the provincial capital is The Hague, while its largest city is Rotterdam. Archaeological discoveries in Hardinxveld-Giessendam indicate that the area of South Holland has been inhabited since at least ca.7,500 years before present, agriculture and permanent settlements probably originated around 2,000 years later, based on excavations near Vlaardingen. In the classical antiquity, South Holland was part of the Roman Province of Germania Inferior, the Romans built fortresses along the border, such as Praetorium Agrippinae near modern-day Valkenburg, Matilo near modern-day Leiden, and Albaniana near modern-day Alphen aan den Rijn. A city was founded near modern-day Voorburg, Forum Hadriani and it was built according to the grid plan, and facilitated a square, a court, a bathhouse and several temples. After the departure of the Romans, the area belonged to the Frisian Kingdom, in 690, the Anglo-Saxon monk Willibrord arrived near Katwijk and was granted permission to spread Roman Catholicism by the Frankish king Pepin II. He accordingly founded a church in Oegstgeest, after which the area was gradually Christianised. The area was appointed to East Francia in the Treaty of Verdun in 843, after which the king granted lands to Gerolf and this was the birth of the County of Holland. Gerolf was later succeeded by Dirk I, who continued to rule Holland under the Frankish king, in 1248, count William II ordered the construction of the Ridderzaal, which was later finished by his son and successor Floris V. The first city in South Holland to receive city rights was Dordrecht, the city retained a dominant position in the area until it was struck by a series of floods in the late 14th century. The same century saw a series of civil wars, the Hook and Cod wars. Both his daughter Jaqueline and his brother John, the supported by Philip the Good, Duke of Burgundy. The conflict ended in 1490, with John victorious, overall, the area of South Holland remained largely agrarian throughout the late Middle Ages. This changed around 1500, when Holland became Europes most urbanised area, during the Eighty Years War, the area of South Holland was the scene of the Capture of Brielle, the Siege of Leiden and the assassination of William the Silent. The United Netherlands declared their independence in 1581, and Holland quickly emerged as the dominant province, with important trading cities such as Leiden, Delft, Gouda. In 1575, the Netherlands first university was founded in Leiden by William the Silent, the Hague, which had originated around the castle of the counts of Holland, became its new political centre. Both the States of Holland and the States General seated in the Binnenhof, the Dutch Golden Age blossomed in the 17th century
3.
Christian Democratic Appeal
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The Christian Democratic Appeal is a Christian-democratic political party in the Netherlands. Sybrand van Haersma Buma has been the party leader since 18 May 2012, the party suffered severe losses in the 2010 general election, losing half of its seats and falling to fourth place in the House of Representatives. Subsequently, the CDA again lost a number of seats in the 2012 general election. Since 1880 the sizeable Catholic and Protestant parties had worked together in the so-called Coalitie and they shared a common interest in public funding of religious schools. In 1888 they formed the first Christian-democratic government, led by the Anti-Revolutionary Æneas Baron Mackay, the cooperation was not without problems and in 1894 the more anti-papist and aristocratic conservatives left the Protestant Anti Revolutionary Party, to found the Christian Historical Union. The main issues dividing Protestants and Catholics was the position of the Dutch Representation at the Holy See, the General League evolved into the Roman Catholic State Party by 1926, and the Catholic Peoples Party in 1945. From 1918 to 1967, the three Christian Democratic parties had a majority in both houses of the States General, and at least two of them were included in every cabinet, the KVP and its antecedents had been in government without interruption since 1918. In the sixties, the Dutch society became more secularized and the pillars faded, in 1963 general election the three parties held 51% of the vote, whilst in 1972 general election they held only 32%. This decline forced the three parties to work closer together, in 1967 the Group of Eighteen was formed, it was a think-tank of six prominent politicians per party that planned the future cooperation of the three parties. In 1968 the three leaders of the parties (Norbert Schmelzer, Barend Biesheuvel and Jur Mellema made a public appearance. This caused progressive forces within the three parties, especially the ARP and KVP, to regret their political affiliation, in 1968 they founded the Political Party of Radicals, a left-wing party that sought cooperation with the Labour Party. Locally and provincially however the three parties had long cooperated well, in areas they formed one Christian-democratic parliamentary party. In the 1971 general election, the three presented a common political program, which lay the foundation for the first Biesheuvel cabinet. After the disastrous elections of 1972 the cooperation was given new momentum, in 1973 this federation was officially formed, with Steenkamp as chairperson. The cooperation was frustrated by the formation of the Den Uyl cabinet, established by the leader of the social-democratic PvdA, Den Uyl refused to allow members of the CHU in the cabinet that he would lead. This led to a situation where the CHU, ARP and KVP sat as a faction in both houses of parliament, but only the KVP and ARP supplied ministers and junior ministers. The cabinet Den Uyl was riddled with political and personal conflicts, another issue that split the three parties was the place that the Bible would take in the new party. In 1976, the three announced that they would field a single list at the 1977 general election under the name Christian Democratic Appeal
4.
Rotterdam
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Rotterdam is a city in the Netherlands, located in South Holland, within the Rhine–Meuse–Scheldt river delta at the North Sea. Its history goes back to 1270 when a dam was constructed in the Rotte river by people settled around it for safety, in 1340 Rotterdam was granted city rights by the Count of Holland and slowly grew into a major logistic and economic centre. Nowadays it is home to Europes largest port and has a population of 633,471, ranking second in the Netherlands, just behind Amsterdam. The Greater Rijnmond area is home to approximately 1.4 million people, Rotterdam is part of the yet larger Randstad conurbation with a total population of 7,100,000. The city of Rotterdam is known for the Erasmus University, riverside setting, lively cultural life, the near-complete destruction of Rotterdams city centre during World War II has resulted in a varied architectural landscape including sky-scrapers, which are an uncommon sight in other Dutch cities. Rotterdam is home to some world-famous architecture from renowned architects like Rem Koolhaas, Piet Blom, Ben van Berkel and others. Recently Rotterdam was listed eighth in The Rough Guide Top 10 Cities to Visit, the port of Rotterdam is the largest cargo port in Europe and the 10th largest in the world. Rotterdams logistic success is based on its location on the North Sea. The rivers Rhine, Meuse, and Scheldt give waterway access into the heart of Western Europe, the extensive distribution system including rail, roads, and waterways have earned Rotterdam the nickname Gateway to Europe, and, conversely, Gateway to the World in Europe. The settlement at the end of the fen stream Rotte dates from at least 900 CE. A dam on the Rotte or Rotterdam was built in the 1260s and was located at the present-day Hoogstraat, on 7 July 1340, Count Willem IV of Holland granted city rights to Rotterdam, which then had approximately 2,000 inhabitants. The port of Rotterdam grew slowly but steadily into a port of importance, becoming the seat of one of the six chambers of the Vereenigde Oostindische Compagnie, the greatest spurt of growth, both in port activity and population, followed the completion of the Nieuwe Waterweg in 1872. The city and harbor started to expand on the bank of the river. The Witte Huis or White House skyscraper, inspired by American office buildings and built in 1898 in the French Château-style, is evidence of Rotterdams rapid growth, when completed, it was the tallest office building in Europe, with a height of 45 m. During World War I the city was the worlds largest spy centre because of Dutch neutrality, many spies who were arrested and executed in Britain were led by German secret agents operating from Rotterdam. MI6 had its main European office on de Boompjes, from there the British coordinated espionage in Germany and occupied Belgium. In WWI an average of 25,000 Belgian refugees lived in the city, as well as hundreds of German deserters, during World War II, the German army invaded the Netherlands on 10 May 1940. Adolf Hitler had hoped to conquer the country in just one day, the Dutch army was finally forced to capitulate on 15 May 1940, following Hitlers bombing of Rotterdam on 14 May and threatening to bomb other Dutch cities
5.
Randstad
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The Randstad is a megalopolis in the central-western Netherlands consisting primarily of the four largest Dutch cities and their surrounding areas. Among other things, it contains the Port of Rotterdam, and Amsterdam Airport Schiphol. With a population of 7,100,000 it is one of the largest metropolitan regions in Europe, comparable in size to Milan or the San Francisco Bay Area and its also one of the most important and densely populated economic areas in northwestern Europe. The Randstads main cities are Almere, Amersfoort, Amsterdam, Delft, Dordrecht, Gouda, Haarlem, Leiden, Rotterdam, The Hague, Utrecht, Zaanstad, and Zoetermeer. Although the name Randstad is often translated into English as edge city or border city, a more accurate translation would be rim city. The Dutch name was coined in 1938 by KLM founder Albert Plesman who, while flying over the region, while technically more of a crescent, the ring shape formed by connecting the four major cities of the region led to the use of the name Ring City. Within the Netherlands, a divide between the Randstad and the rest of the country exists. Recently, Dutch planners have started to refer to the Randstad as Deltametropool, deltametropolis actually consists of two large metropolitan areas,1. The Noordvleugel, consisting of the Haarlem and IJmuiden conurbations in the west, Amsterdam at the centre and Almere, the conurbation of Utrecht can be considered to be part of this wing, but can also be excluded. The cultural centre of the Noordvleugel, however, is centered on Amsterdam. Amsterdam recently started to present itself as the Amsterdam Metropolitan Area, the expectation is that the use of the Noordvleugel and the Randstad will become less as a result. The Zuidvleugel, stretching some 60 kilometers from Dordrecht in the South East to Leiden in the North, the main conurbations are the Rotterdam and The Hague areas. The virtual centre of the Zuidvleugel lies in between two major cities, near Delft. The first steps toward this development were taken with the construction of a new fast light-rail connection between Rotterdam and The Hague, RandstadRail. A long-delayed extension of the western A4-motorway from the south of Delft to Rotterdam has also been constructed, creating a second connection between Rotterdam, via The Hague, to Amsterdam. A possible new area would be the Zuidoostflank, parallel to the A2 motorway and parallel to the A12 motorway, over the last few decades, a major topic in the Randstad is the conflict between the cities and the towns in between. Cities need more space to expand, yet the towns fear losing their identity, the Randstads borders have never been officially specified. Some consider only the four biggest cities of the Netherlands part of it, others would say that such as Alkmaar, Hoorn
6.
Delft University of Technology
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Delft University of Technology, also known as TU Delft, is the largest and oldest Dutch public technological university, located in Delft, Netherlands. With eight faculties and numerous research institutes, it hosts over 19,000 students, more than 3,300 scientists, and more than 2,200 support and management staff. The university was established on 8 January 1842 by King William II of the Netherlands as a Royal Academy, Dutch Nobel laureates Jacobus Henricus van t Hoff, Heike Kamerlingh Onnes, and Simon van der Meer have been associated with TU Delft. TU Delft is a member of several university federations including the IDEA League, CESAER, UNITECH, one of the purposes of the academy was to educate civil servants for the colonies of the Dutch East India Company. The first director of the academy was Antoine Lipkens, constructor of the first Dutch optical telegraph, Royal Academy had its first building located at Oude Delft 95 in Delft. On 23 May 1863 an Act was passed imposing regulations on technical education in the Netherlands, on 20 June 1864, Royal Academy in Delft was disbanded by a Royal Decree, giving a way to a Polytechnic School of Delft. The newly formed school educated engineers of various fields and architects, yet another Act, passed on 22 May 1905, changed the name of the school to Technical College of Delft, emphasizing the academic quality of the education. Polytechnic was granted university rights and was allowed to award academic degrees, the number of students reached 450 around that time. The official opening of the new school was attended by Queen Wilhelmina of the Netherlands on 10 July 1905, First dean of the newly established College was ir. J. Kraus, hydraulic engineer. In 1905, the first doctoral degree was awarded, from 1924 until the construction of the new campus in 1966 the ceremonies were held in the Saint Hippolytus Chapel. Corporate rights were granted to the College on 7 June 1956, most of the university buildings during that time were located within Delft city centre, with some of the buildings set on the side of the river Schie, in the Wippolder district. Student organizations grew together with the university, the first to be established on 22 March 1848 is the Delftsch Studenten Corps housed in the distinctive Sociëteit Phoenix on the Phoenixstraat. This was followed by the Delftsche Studenten Bond|de Delftsche Studenten Bond, in 1917 Proof Garden for Technical Plantation was established by Gerrit van Iterson, which today is known as Botanical Garden of TU Delft. In that period a first female professor, Toos Korvezee, was appointed, after the end of World War II, TU Delft increased its rapid academic expansion. Studium Generale was established at all universities in the Netherlands, including TU Delft, to promote a free and accessible knowledge related to culture, technology, society and science. Because of the number of students, in 1974 the first Reception Week for First Year Students was established. Since 2006 all buildings of the university are located outside of the city center of Delft. Relatively new building of Material Sciences department was sold, later demolished in 2007 to give place for a newly built building of the Haagse Hogeschool, closer cooperation between TU Delft and Dutch universities of applied sciences resulted in physical transition of some of the institutes from outside to Delft
7.
Delftware
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Delftware or Delft pottery, also known as Delft Blue, is blue and white pottery made in and around Delft in the Netherlands and the tin-glazed pottery made in the Netherlands from the 16th century. Delftware in the sense is one of the types of tin-glazed earthenware or faience in which a white glaze is applied. It also forms part of the family of blue and white pottery, using variations of the plant-based decoration first developed in 14th century Chinese porcelain. Delftware includes pottery objects of all such as plates, ornaments. The most highly-regarded period of production is about 1640–1740, the earliest tin-glazed pottery in the Netherlands was made in Antwerp where the Italian potter Guido da Savino settled in 1500. The manufacture of painted pottery spread from Antwerp to the northern Netherlands, production developed in Middelburg and Haarlem in the 1570s and in Amsterdam in the 1580s. Much of the work was produced in Delft, but simple everyday tin-glazed pottery was made in places such as Gouda, Rotterdam, Amsterdam. The main period of pottery in the Netherlands was 1640–1740. From about 1640 Delft potters began using personal monograms and distinctive factory marks. The Guild of St Luke, to which painters in all media had to belong, the Double Tankard, The Young Moors Head, and The Three Bells. The use of marl, a type of rich in calcium compounds, allowed the Dutch potters to refine their technique. The usual clay body of Delftware was a blend of three clays, one local, one from Tournai and one from the Rhineland. From about 1615, the potters began to coat their pots completely in white tin glaze instead of covering only the painting surface and coating the rest with clear ceramic glaze. They then began to cover the tin-glaze with clear glaze, which gave depth to the surface and smoothness to cobalt blues. During the Dutch Golden Age, the Dutch East India Company had a trade with the East. The Chinese workmanship and attention to detail impressed many, only the richest could afford the early imports. Dutch potters did not immediately imitate Chinese porcelain, they began to do so after the death of the Wanli Emperor in 1620, potters now saw an opportunity to produce a cheap alternative for Chinese porcelain. After much experimenting they managed to make a type of earthenware which was covered with a white tin glaze
8.
House of Orange-Nassau
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Several members of the house served during this war and after as governor or stadtholder during the Dutch Republic. However, in 1815, after a period as a republic. The dynasty was established as a result of the marriage of Henry III of Nassau-Breda from Germany and their son René inherited in 1530 the independent and sovereign Principality of Orange from his mothers brother, Philibert of Châlon. As the first Nassau to be the Prince of Orange, René could have used Orange-Nassau as his new family name, however, his uncle, in his will, had stipulated that René should continue the use of the name Châlon-Orange. History knows him therefore as René of Châlon, after the death of René in 1544 his cousin William of Nassau-Dillenburg inherited all his lands. This William I of Orange, in English better known as William the Silent, the Castle of Nassau was founded around 1100 by Count Dudo-Henry of Laurenburg, the founder of the House of Nassau. In 1120, Dudo-Henrys sons and successors, Counts Robert I and Arnold I of Laurenburg and they renovated and extended the castle complex in 1124. The first man to be called the count of Nassau was Robert I of Nassau, the Nassau family married into the family of the neighboring Counts of Arnstein. His sons Walram and Otto split the Nassau possessions, the descendants of Walram became known as the Walram Line, which became Dukes of Nassau, and in 1890, the Grand Dukes of Luxembourg. This line also included Adolph of Nassau, who was elected King of the Romans in 1292, the descendants of Otto became known as the Ottonian Line, which inherited parts of Nassau County, and properties in France and the Netherlands. The House of Orange-Nassau stems from the younger Ottonian Line, the first of this line to establish himself in the Netherlands was John I, Count of Nassau-Dillenburg, who married Margareta of the Marck. The real founder of the Nassau fortunes in the Netherlands was Johns son and he became counsellor to the Burgundian Dukes of Brabant, first to Anton of Burgundy, and later to his son Jan IV of Brabant. He also would later serve Philip the Good, in 1403 he married the Dutch noblewoman Johanna van Polanen, and so inherited lands in the Netherlands, with the Barony of Breda as the core of the Dutch possessions and the family fortune. A nobles power was based on his ownership of vast tracts of land. It also helped that much of the lands that the House of Orange and Nassau controlled sat under one of the commercial and mercantile centers of the world (see below under Lands and Titles. The importance of the Nassaus grew throughout the 15th and 16th centuries as they became councilors, generals, Engelbert II of Nassau served Charles the Bold and Maximilian I, Holy Roman Emperor, who had married Charless daughter Mary of Burgundy. In 1496 he was appointed stadtholder of Flanders and by 1498 he had been named President of the Grand Conseil, in 1501, Maximilian named him Lieutenant-General of the Seventeen Provinces of the Netherlands. From that point forward, Engelbert was the representative of the Habsburg Empire to the region
9.
Dutch Golden Age
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The Dutch Golden Age was a period in Dutch history, roughly spanning the 17th century, in which Dutch trade, science, military, and art were among the most acclaimed in the world. The first half is characterized by the Eighty Years War which ended in 1648, the Golden Age continued in peacetime during the Dutch Republic until the end of the century. The Netherlandss transition from a possession of the Holy Roman Empire in the 1590s to the foremost maritime, in 1568, the Seven Provinces that later signed the Union of Utrecht started a rebellion against Philip II of Spain that led to the Eighty Years War. Antwerp fell on August 17,1585 after a siege, the United Provinces fought on until the Twelve Years Truce, which did not end the hostilities. Under the terms of the surrender of Antwerp in 1585, the Protestant population were given four years to settle their affairs before leaving the city, similar arrangements were made in other places. Protestants were especially well-represented among the craftsmen and rich merchants of the port cities of Bruges, Ghent. More moved to the north between 1585 and 1630 than Catholics moved in the direction, although there were also many of these. Many of those moving north settled in Amsterdam, transforming what was a port into one of the most important ports. The Pilgrim Fathers also spent time there before their voyage to the New World, Ronald Findlay and Kevin H. O’Rourke contribute part of the Dutch ascendancy to its Calvinistic ethic, which promoted thrift and education. This contributed to the lowest interest rates and the highest literacy rates in Europe, several other factors also contributed to the flowering of trade, industry, the arts and the sciences in the Netherlands during this time. A necessary condition was a supply of energy from windmills and from peat. The invention of the sawmill enabled the construction of a massive fleet of ships for worldwide trading. In 1602 the Dutch East India Company was founded and it was the first-ever multinational corporation, financed by shares that established the first modern stock exchange. This company received a Dutch monopoly on Asian trade and would keep this for two centuries and it became the worlds largest commercial enterprise of the 17th century. Spices were imported in bulk and brought huge profits, due to the efforts and risks involved and this is remembered to this day in the Dutch word peperduur, meaning something is very expensive, reflecting the prices of spices at the time. To finance the trade within the region, the Bank of Amsterdam was established in 1609. According to Ronald Findlay and Kevin H. O’Rourke, geography favored the Dutch Republic and they write, The foundations were laid by taking advantage of location, midway between the Bay of Biscay and the Baltic. The Dutch share of European shipping tonnage was enormous, well over half during most of the period of their ascendancy, from here the Dutch traded between China and Japan and paid tribute to the Shogun
10.
Microbiology
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Microbiology is the study of microscopic organisms, those being unicellular, multicellular, or acellular. Microbiology encompasses numerous sub-disciplines including virology, mycology, parasitology, microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the present in common environments can be cultured in isolation using current means. Microbiologists often rely on extraction or detection of nucleic acid, either DNA or RNA sequences, viruses have been variably classified as organisms, as they have been considered either as very simple microorganisms or very complex molecules. As an application of microbiology, medical microbiology is often introduced with medical principles of immunology as microbiology and immunology, otherwise, microbiology, virology, and immunology as basic sciences have greatly exceeded the medical variants, applied sciences. The existence of microorganisms was hypothesized for many centuries before their actual discovery, the existence of unseen microbiological life was postulated by Jainism which is based on Mahavira’s teachings as early as 6th century BCE. Paul Dundas notes that Mahavira asserted existence of unseen microbiological creatures living in earth, water, air, in 1546, Girolamo Fracastoro proposed that epidemic diseases were caused by transferable seedlike entities that could transmit infection by direct or indirect contact, or vehicle transmission. However, early claims about the existence of microorganisms were speculative, actual observation and discovery of microbes had to await the invention of the microscope in the 17th century. In 1676, Anton van Leeuwenhoek, who lived most of his life in Delft, Holland, observed bacteria and other microorganisms using a single-lens microscope of his own design. While Van Leeuwenhoek is often cited as the first to observe microbes, Robert Hooke made the first recorded microscopic observation, of the bodies of moulds. It has, however, been suggested that a Jesuit priest called Athanasius Kircher was the first to observe micro-organisms and he was among the first to design magic lanterns for projection purposes, so he must have been well acquainted with the properties of lenses. One of his books contains a chapter in Latin, which reads in translation – Concerning the wonderful structure of things in nature, here, he wrote who would believe that vinegar and milk abound with an innumerable multitude of worms. He also noted that material is full of innumerable creeping animalcule. These observations antedate Robert Hookes Micrographia by nearly 20 years and were published some 29 years before van Leeuwenhoek saw protozoa and 37 years before he described having seen bacteria. Joseph Lister was the first person who said infectious diseases are caused by micro-organism and was first person who used phenol as disinfectant on the wounds of patients. Cohn was also the first to formulate a scheme for the classification of bacteria. Louis Pasteur and Robert Koch were contemporaries of Cohn’s and are considered to be the father of microbiology and medical microbiology. Pasteur is most famous for his series of experiments designed to disprove the widely held theory of spontaneous generation
11.
History of virology
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The history of virology – the scientific study of viruses and the infections they cause – began in the closing years of the 19th century. Although Louis Pasteur and Edward Jenner developed the first vaccines to protect against viral infections, the first evidence of the existence of viruses came from experiments with filters that had pores small enough to retain bacteria. In 1892, Dmitry Ivanovsky used one of these filters to show that sap from a tobacco plant remained infectious to healthy tobacco plants despite having been filtered. Martinus Beijerinck called the filtered, infectious substance a virus and this discovery is considered to be the beginning of virology, the subsequent discovery and partial characterization of bacteriophages by Felix dHerelle further catalyzed the field, and by the early 20th century many viruses were discovered. Despite his other successes, Louis Pasteur was unable to find an agent for rabies. In 1884, the French microbiologist Charles Chamberland invented a filter – known today as the Chamberland filter – that had pores smaller than bacteria, thus, he could pass a solution containing bacteria through the filter and completely remove them from the solution. In 1892, the Russian biologist Dmitry Ivanovsky used a Chamberland filter to study what is now known as the tobacco mosaic virus and his experiments showed that crushed leaf extracts from infected tobacco plants remain infectious after filtration. Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, in 1898, the Dutch microbiologist Martinus Beijerinck repeated the experiments and became convinced that filtrate contained a new form of infectious agent. He observed that the agent multiplied only in cells that were dividing and he called it a contagium vivum fluidum and re-introduced the word virus. Beijerinck maintained that viruses were liquid in nature, a theory later discredited by the American biochemist and virologist Wendell Meredith Stanley, in the same year Friedrich Loeffler and Paul Frosch passed the first animal virus through a similar filter and discovered the cause of foot-and-mouth disease. In 1881, Carlos Finlay, a Cuban physician, first suggested that mosquitoes were carrying the cause of yellow fever, during 1901 and 1902, William Crawford Gorgas organised the destruction of the mosquitoes breeding habitats in Cuba, which dramatically reduced the prevalence of the disease. Gorgas later organised the elimination of the mosquitoes from Panama, which allowed the Panama Canal to be opened in 1914, the virus was finally isolated by Max Theiler in 1932 who went on to develop a successful vaccine. By 1928 enough was known about viruses to enable the publication of Filterable Viruses, Rivers, a survivor of typhoid fever contracted at the age of twelve, went on to have a distinguished career in virology. From the 1950s to the 1960s, Chester M and he was also examining if one could become immune to cancer by developing an acquired immune response in hopes of creating a vaccine for cancer. The notion that viruses were particles was not considered unnatural and fitted in nicely with the germ theory, the sizes of viruses determined using this new microscope fitted in well with those estimated by filtration experiments. Viruses were expected to be small, but the range of sizes came as a surprise, some were only a little smaller than the smallest known bacteria, and the smaller viruses were of similar sizes to complex organic molecules. In 1935, Wendell Stanley examined the tobacco mosaic virus and found it was made of protein. In 1939, Stanley and Max Lauffer separated the virus protein and nucleic acid
12.
Cornelis Springer
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Cornelis Springer, was a Dutch 19th century landscape painter. He was a pupil of his father, the carpenter Willem Springer and he was a pupil of Hendrik Gerrit ten Cate, Kasparus Karsen, and Jacobus van der Stok. He became a member of the Amsterdam painters collective Felix Meritis and he is known for watercolors, etchings, and drawings, especially of city views and town scenes that he sketched while traveling around the country. He was awarded the Leopold order of Belgium in 1865, and his son Leonard Springer became a landscape architect
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South Holland
listen)) is a city and municipality in the province of South Holland, Netherlands. It is located between Rotterdam, to the southeast, and The Hague, to the northwest. Together with them, it is part of both Rotterdam–The Hague metropolitan area and the Randstad.
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Delft
