Delta Connection is a brand name for Delta Air Lines, under which a number of individually owned regional airlines primarily operate short- and medium-haul routes. Mainline major air carriers often use regional airlines to operate services via code sharing agreements in order to increase frequencies in addition to serving routes that would not sustain larger aircraft as well as for other competitive or operational reasons.

Delta Air Lines is one of the major airlines of the United States and a legacy carrier headquartered in Atlanta, Georgia. The United States' oldest operating airline and the seventh-oldest operating worldwide, Delta along with its subsidiaries and regional affiliates, including Delta Connection, operates over 5,400 flights daily and serves 325 destinations in 52 countries on six continents. Delta is a founding member of the SkyTeam airline alliance. As of the end of 2022, it had 90,000 employees.