The Denaʼina, or formerly Tanaina, are an Alaska Native Athabaskan people. They are the original inhabitants of the south central Alaska region ranging from Seldovia in the south to Chickaloon in the northeast, Talkeetna in the north, Lime Village in the northwest and Pedro Bay in the southwest. The Denaʼina homeland is more than 41,000 sq mi (110,000 km2) in area. They arrived in the south-central Alaska sometime between 1,000 and 1,500 years ago. They were the only Alaskan Athabaskan group to live on the coast. The Denaʼina have a hunter-gatherer culture and a matrilineal system. The Iditarod Trail's antecedents were the native trails of the Denaʼina and Deg Hitʼan Athabaskan Native Alaskans and the Inupiaq Inuit.

Alaska Natives are the Indigenous peoples of Alaska and include Alaskan Creoles, Iñupiat, Yupik, Aleut, Eyak, Tlingit, Haida, Tsimshian, and a number of Northern Athabaskan cultures. They are often defined by their language groups. Many Alaska Natives are enrolled in federally recognized Alaska Native tribal entities, who in turn belong to 13 Alaska Native Regional Corporations, who administer land and financial claims.