Denver Union Station is the main railway station and central transportation hub in Denver, Colorado. It is located at 17th and Wynkoop Streets in the present-day LoDo district and includes the historic station house, a modern open-air train shed, a 22-gate underground bus station, and light rail station. A station was first opened on the site on June 1, 1881, but burned down in 1894. The current structure was erected in two stages, with an enlarged central portion completed in 1914.

Denver is a consolidated city and county, the capital, and most populous city of the U.S. state of Colorado. Its population was 715,522 at the 2020 census, a 19.22% increase since 2010. It is the 19th-most populous city in the United States and the fifth most populous state capital. It is the principal city of the Denver–Aurora–Lakewood metropolitan statistical area, the most populous metropolitan statistical area in Colorado and the first city of the Front Range Urban Corridor.