Department S is a British spy-fi adventure series, produced by ITC Entertainment. It consists of 28 episodes which originally aired in 1969 and 1970. It stars Peter Wyngarde as author Jason King, Joel Fabiani as Stewart Sullivan, and Rosemary Nicols as computer expert Annabelle Hurst. These three are agents for a fictional special department of Interpol. The head of Department S is Sir Curtis Seretse.

The Incorporated Television Company (ITC), or ITC Entertainment as it was referred to in the United States, was a British company involved in production and distribution of television programmes.