Apurímac is a department and region in southern-central Peru. It is bordered on the east by the Cusco Region, on the west by the Ayacucho Region, and on the south by the Arequipa and Ayacucho regions. The region's name originates from the Quechua language and means "where the gods speak" in reference to the many mountains of the region that seem to be talking to each other.

Cusco, also spelled Cuzco, is a department and region in Peru and is the fourth largest department in the country, after Madre de Dios, Ucayali, and Loreto. It borders the departments of Ucayali on the north; Madre de Dios and Puno on the east; Arequipa on the south; and Apurímac, Ayacucho and Junín on the west. Its capital is Cusco, the historical capital of the Inca Empire.