Arequipa is a department and region in southwestern Peru. It is the sixth largest department in Peru, after Puno, Cuzco, Madre de Dios, Ucayali, and Loreto, its sixth most populous department, and its eleventh least densely populated department. It is bordered by the departments of Ica, Ayacucho, Apurímac and Cusco in the north, the Department of Puno in the east, the Department of Moquegua in the south, and the Pacific Ocean in the west. Its capital, also called Arequipa, is Peru's second-largest city.

Puno is a department and region in southeastern Peru. It is the fifth largest department in Peru, after Cuzco, Madre de Dios, Ucayali, and Loreto. It is bordered by Bolivia on the east, the departments of Madre de Dios on the north, Cusco and Arequipa on the west, Moquegua on the southwest, and Tacna on the south. Its capital is the city of Puno, which is located on Lake Titicaca in the geographical region known as the Altiplano or high sierra.