Puno is a department and region in southeastern Peru. It is the fifth largest department in Peru, after Cuzco, Madre de Dios, Ucayali, and Loreto. It is bordered by Bolivia on the east, the departments of Madre de Dios on the north, Cusco and Arequipa on the west, Moquegua on the southwest, and Tacna on the south. Its capital is the city of Puno, which is located on Lake Titicaca in the geographical region known as the Altiplano or high sierra.

Cusco, also spelled Cuzco, is a department and region in Peru and is the fourth largest department in the country, after Madre de Dios, Ucayali, and Loreto. It borders the departments of Ucayali on the north; Madre de Dios and Puno on the east; Arequipa on the south; and Apurímac, Ayacucho and Junín on the west. Its capital is Cusco, the historical capital of the Inca Empire.