Depew is a village in Erie County, New York. The population was 15,303 at the time of the 2010 census. It is part of the Buffalo–Niagara Falls metropolitan area. The village is named for Chauncey Depew, a politician and one of the original investors who bought the land for the village, which was incorporated in 1894.

Patrick Edward Dobson, Jr. was an American right-handed starting pitcher in Major League Baseball who played for the Detroit Tigers (1967–69), San Diego Padres (1970), Baltimore Orioles (1971–72), Atlanta Braves (1973), New York Yankees (1973–75) and Cleveland Indians (1976–77). He was best known for being one of four Orioles pitchers to win 20 games in their 1971 season.