The deputy prime minister of Croatia is the official deputy of the Prime Minister of Croatia. Article 109 of the Constitution of Croatia states that the cabinet is to be made up of the Prime Minister, one or more deputy prime ministers and other cabinet ministers. According to convention, if the governing parliamentary majority is a coalition of parties, all junior partners in the coalition will usually be given one deputy prime minister in the cabinet, with their rank usually being determined by the number of MPs the party has in Parliament. The deputy prime ministers are permitted to simultaneously hold a ministerial portfolio while in office, but may also serve without holding such a portfolio.

The prime minister of Croatia, officially the president of the government of the Republic of Croatia, is Croatia's head of government, and is de facto the most powerful and influential state officeholder in the Croatian system of government. Following the first-time establishment of the office in 1945, the 1990–2000 semi-presidential period is the only exception where the president of Croatia held de facto executive authority. In the formal Croatian order of precedence, however, the position of prime minister is the third highest state office, after the president of the Republic and the speaker of the Parliament.