Derek S. Lyons is an American attorney and former White House Staff Secretary and Counselor to the President in the administration of former U.S. President Donald Trump.

The Staff Secretary is a position in the White House Office responsible for managing paper flow to the President and circulating documents among senior staff for comment. It has been referred to as "the nerve center of the White House." Specifically, the Office of the Staff Secretary decides which decision memos, briefing materials, lists of potential nominees, briefing books, intelligence reports, schedules, correspondence, and speech drafts end up on the president’s desk, as well as how and when the president will receive them. The Staff Secretary also works with senior White House staff to edit all of these materials and ensure they are ready for the president's consumption.