Derwent Mouth is a location on the River Trent, which at that point forms the border between the English counties of Derbyshire and Leicestershire. It is both the confluence of the River Derwent with the River Trent, and the point at which the Trent and Mersey Canal joins the natural River Trent.

The Trent and Mersey Canal is a 93+1⁄2-mile (150 km) canal in Derbyshire, Staffordshire and Cheshire in north-central England. It is a "narrow canal" for the vast majority of its length, but at the extremities to the east of Burton upon Trent and north of Middlewich, it is a wide canal.