Des Arc is a city on the White River in the Arkansas Delta, United States. It is the largest city in Prairie County, Arkansas, and the county seat for the county's northern district. Incorporated in 1854, Des Arc's position on the river has shaped its culture, history, and economy, beginning as a major lumber shipping port but leaving the city vulnerable to major floods in 1927 and 1937. As river shipping declined, Des Arc was bypassed by railroads, Interstate highways, and much of the post-industrial society. Des Arc's history is preserved by seven listings on the National Register of Historic Places, and the region's history is interpreted at Lower White River Museum State Park. The city's population stopped growing in the 1980s and has been declining since, with a population of 1,717 at the 2010 Census.

Prairie County is in the Central Arkansas region of the U.S. state of Arkansas. The county is named for the Grand Prairie, a subregion of the Arkansas Delta known for rice cultivation and aquaculture that runs through the county. Created as Arkansas's 54th county in 1846, Prairie County is home to four incorporated towns, including DeValls Bluff, the southern district county seat, and two incorporated cities, including Des Arc, the northern district county seat. The county is also the site of numerous unincorporated communities and ghost towns. Occupying 676 square miles (175,000 ha), Prairie County is the median-sized county in Arkansas. As of the 2020 Census, the county's population was 8,282. Based on population, the county is the ninth-smallest county of the 75 in Arkansas.