Des Clarke is a fictional character from the Australian soap opera Neighbours, played by Paul Keane. Des was created by Reg Watson as one of Neighbours' twelve original characters. He made his first on screen appearance on 18 March 1985, the show's first episode. Des departed during the episode broadcast on 11 October 1990. Keane later reprised the role as part of Neighbours' 30th anniversary celebrations in March 2015. He also returned for the 35th anniversary on 18 March 2020, again in August and December 2020 and for the serial's final episodes in 2022.

The Neighbours 30th Anniversary was a series of celebrations to mark the 30th anniversary of Australian television soap opera Neighbours. The celebrations span over two weeks, beginning on 4 March 2015 in Australia, while starting on 18 March in the United Kingdom. The anniversary features many storylines, but points around Paul Robinson's Erinsborough festival and the wedding of Daniel Robinson and Amber Turner. The serial's executive producer, Jason Herbison, began planning the 30th anniversary over a year in advance. Over ten former cast members from all eras of the show were invited back to "honour the past and present". Kylie Minogue and Jason Donovan were also invited, but they both downturned the offer. The celebrations marked Ian Smith and Anne Charleston's returns to Neighbours as Harold and Madge Bishop respectively. Madge was last seen during her death in 2001 and returns as a ghost in Harold's mind, which Herbison was initially worried would not be accepted by Charleston nor Smith, however both approved of it. The storyline was also popular amongst viewers.